The £11 million hotel, due to open this summer, will be developed under a franchise agreement with developer Scot Sheridan and property firm Curo West Campbell LLP.
The project will see the property, a former office building on the city’s West Campbell Street, transformed into an 88-bedroom hotel with its own 24-hour fitness centre.
Patrick Fitzgibbon, senior vice president, development, Europe and Africa, at Hilton Worldwide, said the new hotel would complement the group’s “strong presence” in the city.
“Visitor numbers to the city are expected to grow by up to one million a year until 2016 so the time is right to go on to expand our portfolio here,” said Fitzgibbon.
“Having successfully opened Hilton Garden Inn Glasgow City Centre two years ago we are delighted to be providing further choice for guests seeking affordable, quality, centrally-located accommodation with our debut Hampton by Hilton.”
When it opens, the hotel will offer guests free high-speed internet access, an all-night snack bar and breakfast included in their room rate.
Phil Cordell, global head of Hampton by Hilton, said with major events such as the Commonwealth Games and Ryder Cup “the eyes of the world will be on Scotland”.
“As a result there can be no better time for us to introduce our own gold medal-winning brand to the country,” he said.